Roxtal XP 250 Uses, Side Effect, Price in Bangladesh

Indication/Uses
• Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
• Acute Bacterial Otitis Media caused by Streptococcus pneumoniae,
• Haemophilus influenzae (including beta- lactamase producing strains),
• Moraxella catarrhalis (including beta-lactamase producing strains) or
• Streptococcus pyogenes.
• Acute Bacterial Maxillary Sinusitis caused by Streptococcus
• pneumoniae or Haemophilus influenzae.
• Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary
• Bacterial Infections of Acute Bronchitis caused by Streptococcus
• pneumoniae, Haemophilus influenzae or Haemophilus parainfluenzae.
• Uncomplicated Skin and Skin-Structure Infections caused by
• Staphylococcus aureus (including beta-lactamase producing strains) or
• Streptococcus pyogenes.
• Uncomplicated Urinary Tract Infections caused by Escherichia coli or
• Klebsiella pneumoniae.
• Uncomplicated Gonorrhea (urethral and endocervical) caused by
• Neisseria gonorrhoeae and Uncomplicated Gonorrhea, rectal, in females,
• caused by non-penicillinase producing strains of Neisseria gonorrhoeae.
• Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi.
• Septicemia caused by Staphylococcus aureus, Streptococcus
• pneumoniae, Escherichia coli, Haemophilus influenzae (including
• ampicillin-resistant strains) and Klebsiella spp.
• Meningitis caused by Streptococcus pneumoniae, Haemophilus
• influenzae (including ampicillin-resistant strains), Neisseria meningitidis
• and Staphylococcus aureus (penicillinase and non-penicillinase
• producing strains).
• Switch therapy (injectable to oral).
Pharmacology/Description
Cefuroxime is a broad spectrum second generation Cephalosporin
active against a wide range of Gram-positive and Gram-negative
susceptible organisms including many beta-Iactamase producing
strains. The bactericidal action of Cefuroxime results from inhibition of
cell wall synthesis by binding to essential target proteins. Cefuroxime
has good stability to bacterial beta-lactamases.
Clavulanic Acid has a similar structure to the beta-lactam antibiotics but
binds irreversibly to the beta-lactamase enzymes. The presence of
Clavulanic Acid protects Cefuroxime from degradation by
beta-Iactamase enzymes and effectively extends the antibacterial
spectrum of Cefuroxime to include many bacteria normally resistant to
Cefuroxime and other Cephalosporins
Dosage and Administration
Adolescents and adults (13 years and older)-
Pharyngitis/tonsillitis: 25° mg b.i.d. for 5-10 days
Acute bacterial maxillary sinusitis: 25° mg b.i.d. for 10 days
Acute bacterial exacerbation of chronic bronchitis: 25°-500 mg b.i.d. for 10 days
Secondary bacterial infections of acute bronchitis: 25°-500 mg b.i.d. for 5-10 days
Uncomplicated skin and skin structure infections: 25°-500 mg b.i.d. for 10 days
Uncomplicated urinary tract infections: 25° mg b.i.d. for 7-10 days
Uncomplicated Gonorrhoea: 1000 mg Single dose
Community acquired pneumonia: 25°-500 mg b.i.d. for 5-10 days
MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
Early Lyme disease: 500 mg b.i.d. for 2° days
Paediatric Patients (3 months to 12 years)-
Pharyngitis/Tonsillitis: 2° mg/kg/day b.i.d for 5-10 days
Acute otitis media: 30 mg/kg/day b.i.d for 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
Impetigo: 30 mg/kg/day b.i.d for 10 days
Interaction
Concomitant administration of Probenecid with
Cefuroxime-Clavulanic Acid increases the area under the serum
concentration versus time curve by 50%. Drug that reduces gastric
acidity may result in a lower bioavailability of Cefuroxime and tend to
cancel the effect of postprandial absorption.
Contraindication
Cefuroxime-Clavulanic Acid is contraindicated in patients with known
allergy to Cephalosporins & in patients with Pseudomembranous
Colitis.
Side Effect
Generally Cefuroxime-Clavulanic Acid is well tolerated. Major adverse
• reactions which may occur are diarrhea
• nausea
• vomiting
• transient
• elevation in AST
• ALT
• LDH and eosinophilia. Other adverse events that
• may occur are abdominal pain
• abdominal cramps
• flatulence

• indigestion
• headache
• vaginitis
• rash
• itch
• dysuria
• sleepiness
• thirst

• anorexia etc.
Pregnancy and Lactation
All antibiotics should be avoided in the first trimester if possible.
However, Cefuroxime-Clavulanic Acid can be safely used in later
pregnancy to treat Urinary Tract and other infections.
Cefuroxime-Clavulanic Acid is excreted into the breast milk in small
quantities and consequently caution should be exercised when it is
administered to a nursing mother.
Overdose Effects
Excessively large doses of all Cephalosporins can cause cerebral
irritation and may cause convulsions. This complication is unlikely to
occur in routine practice unless the patient is in renal failure
Storage Conditions
Tablet: Store below 25
C, protected from light & moisture. Keep out of
reach of children.
Suspension: Store below 25
C, protected from light and moisture.
After reconstitution, keep the suspension in refrigerator (2
- 8°
C) and
use within 7 days.
Reconstitution
For Suspension: Shake the bottle well before adding water. Then add
35 ml of boiled and cooled water (with the help of the provided cup) to
the bottle. Then continue shaking the bottle until the powder is
dissolved properly.
Therapeutic Class
Second generation Cephalosporins
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Kefuclav 500

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50.00 TK

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Mexclav 500

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30.00 TK

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50.00 TK

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50.20 TK

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Fuclav-250

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30.10 TK

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18.10 TK

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250.75 TK

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50.20 TK

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30.10 TK

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Fuclav 125

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18.10 TK

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Roxiclav-500

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50.00 TK

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30.00 TK

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50.00 TK

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30.00 TK

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Secoclav 500

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50.00 TK

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Furoget CV

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Furoget CV 250

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28.00 TK

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Furoget CV 500

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48.00 TK

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18.00 TK

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Ximeclav 250

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30.00 TK

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Ximeclav 500

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18.00 TK

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Clacef 250 mg

250 mg + 62.5 m ...

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30.00 TK

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Clacef 500 mg

500 mg + 125 mg

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50.00 TK

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18.05 TK

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250 mg + 62.5 m ...

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35.00 TK

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55.00 TK

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250 mg + 62.5 m ...

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250.00 TK

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250 mg + 62.5 m ...

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30.00 TK

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125 mg + 31.25 ...

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252.00 TK

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125 mg + 31.25 ...

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18.00 TK

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Axicef Plus 250/62.5

250 mg + 62.5 m ...

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30.00 TK

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Axicef Plus 500/125

500 mg + 125 mg

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125 mg + 31.25 ...

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125 mg + 31.25 ...

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250.00 TK

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